I read an article the other day claiming that Monday was the best time to apply for a job. It states that:
“...getting your application early gives a hiring manager time to discuss it with colleagues and arrange meetings in the same week. Applications that come in later may have a higher chance of falling between the cracks or getting pushed aside.”
That sounds like safe reasoning, but I doubt it really holds much weight. Here is when I think the best time to apply for a job is: before the position close date and after you have had enough to time to thoughtfully target your resume and cover letter towards the specific opportunity. If that coincides with a Monday, great.